Fall 2013



Instructor:                            Dr. Inder M. Saxena

Office:                                    NMS 4.312

Office hours:                        M         10:00 – 12:00 noon

                                                W        11:00 – 12:00 noon

(or by appointment)                      




LECTURE                                        M, W, F           2:00 - 3:00 PM          (WAG 420)


                                    Unique #

DISCUSSION           50155             M                     1:00 - 2:00 PM          (GAR 0.132)

                                    50160             M                     3:00 - 4:00 PM          (JES A303A)

                                    50165             M                     4:00 - 5:00 PM          (JES A305A)



Course objectives

The objective of this course is to provide an overview of genetics in terms of understanding the principles and the tools used for studying the various genetic processes.  Although a balanced approach has been followed in organizing this course, emphasis has been placed on the molecular aspects.  Problem-solving skills will be emphasized throughout the course and it is expected that students will make use of the excellent problems provided in the textbook.


Text Book

Genetics: A Conceptual Approach (Fourth Edition) Pierce.

W. H. Freeman and Company.



1.     DNA from the beginning

2.     Beyond the gene (an article that discusses an evolving view of the term gene)

3.     What is a gene, post-ENCODE? History and updated definition

4.     Gene: An Evolving Concept

5.     Human Genome landmarks: Selected Genes, Traits, and Disorders (get a free wall poster)

6.     Mule's foal fools genetics

7.     The Ultimate Pedigree Challenge

8.     Super Pedigree Analysis

9.     Double Helix: 50 years of DNA


How to Increase Your Chances of Success in Genetics (page 1, 2, 3, 4, 5) From: Student Handbook and Solutions Manual, by Harry Nickla


Lecture topics


                                                Lecture topics                                   Chapter(s)




Basic principles of heredity: Segregation

and Independent Assortment                          3


Chromosomes in mitosis and meiosis            2


Sex determination and sex-linked traits         4


Extensions and modifications of basic

principles of heredity                                       5


                                                Pedigree analysis, applications, and

genetic testing                                     6


Linkage, recombination, and mapping

of eukaryotic chromosomes                           7



                                                Bacterial and viral genetic systems                8


DNA: Structure, replication, and

recombination                                                 10, 12


Chromosome structure and transposable

elements                                                         11


Transcription, RNA molecules, and

RNA processing                                              13, 14

Genetic code and Translation             15

Control of gene expression in prokaryotes     16

Control of gene expression in eukaryotes      17


                                                Gene mutations and DNA repair                    18


Chromosome variation                                   9


Molecular genetic analysis and

biotechnology                                      19


Genomics and proteomics                             20


Cancer genetics                                              23


Population genetics                                         25


In science, self-satisfaction is death.  Personal self-satisfaction is the death of the scientist.  Collective self-satisfaction is the death of the research.  It is restlessness, anxiety, dissatisfaction, agony of mind that nourish science.
                            - Jacques Monod (1910-1977)